In the skin, the disease causes palpable purpura small, raised areas of bleeding underneath the skin , often with joint pain and abdominal pain. With kidney involvement, there may be a loss of small amounts of blood and protein in the urine hematuria and proteinuria , but this usually goes unnoticed; in a small proportion of cases, the kidney involvement proceeds to chronic kidney disease. HSP is often preceded by an infection , such as a throat infection. HSP is a systemic vasculitis inflammation of blood vessels and is characterized by deposition of immune complexes containing the antibody immunoglobulin A IgA ; the exact cause for this phenomenon is unknown.
Successful treatment of Henoch-Schonlein purpura nephritis with plasma exchange in an adult male
IgA Nephropathy and IgA Vasculitis (Henoch-Schönlein Purpura) Nephritis | Abdominal Key
Henoch-Schonlein purpura is an inflammation of the small blood vessels of the skin, joints, bowels and kidneys. When blood vessels get inflamed, they can bleed into the skin, causing a reddish-purple rash purpura. Henoch-Schonlein purpura also known as IgA vasculitis is a disorder that causes the small blood vessels in your skin, joints, intestines, and kidneys to become inflamed and bleed. The most striking feature of this form of vasculitis is a purplish rash, typically on the lower legs and buttocks.
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Differences between adult and pediatric onset Henoch-Schonlein purpura from North India
Henoch-Schonlein purpura HSP is a form of vasculitis or inflammation of the blood vessels. HSP affects the capillaries in the skin causing bleeding which appears as a purplish rash most commonly on the buttocks and lower legs. Sometimes joint pain or abdominal pain accompanies it and HSP commonly affects the kidneys. Henoch-Schonlein purpura most often occurs in the spring after the person has had a bacterial or viral upper respiratory infection. It is thought that HSP is the result of an immune reaction after the illness though drugs or certain vaccinations can also trigger a HSP response.
The inflammation typically affects smaller blood vessels, resulting in a severe skin rash or bruise-like appearance on the skin. Other symptoms of HSP might include arthritis inflammation of the joints or nephritis inflammation of blood vessels in the kidney. Inflammation can also occur in other organs of the body. HSP typically affects kids between the ages of 2 and 10, although older children may also suffer from it too.